G2001-3 – GR PNA-S – Globin Blocking PNA – 3 nmole

GR PNA-S is a set of 4 PNA oligos specifically designed to bind and block human globin transcripts, reducing their amplification during reverse transcription and improving RNA-seq coverage for low-abundance genes.

This blocking strategy enhances transcriptome profiling of blood-derived RNA by preventing highly expressed globin mRNAs from dominating the sequencing data. Built on PNA chemistry, the oligos resist enzymatic degradation and hybridize with high affinity to globin targets, offering a clean and efficient solution to common globin interference issues in blood-based RNA sequencing.

• Includes 4 PNA oligos targeting both alpha and beta globin genes
• Improves transcriptome depth from whole blood RNA
• Reduces high-abundance globin interference in RNA-seq
• PNA backbone ensures high stability and specificity
• Compatible with RT-PCR, cDNA prep, and sequencing
• Optimized for high-efficiency globin transcript suppression

• Whole blood RNA sequencing and transcriptomics
• Pre-treatment step for reverse transcription reactions
• Enhanced detection of low-abundance transcripts
• Clinical diagnostics using blood-based RNA
• Gene expression profiling in hematological samples
• Globin depletion from blood-derived RNA libraries

• 4 PNA oligos targeting human globin transcripts
• Combined total of 3 nmole per set
• Instructions for reconstitution and RNA workflow integration
• Technical support for RNA-seq setup

Need help integrating globin blockers into your workflow? Contact our support team for RNA-seq optimization and best practices.