CS01-50 – SniperCas9 – High Fidelity Cas9 Protein with NLS – 50 µg

SniperCas9 is a high fidelity Cas9 protein engineered for precision genome editing. With enhanced targeting specificity and dramatically reduced off-target activity, it is the preferred choice for researchers requiring clean edits in sensitive applications. This product reconstitutes to 1 mg/ml and delivers 300 pmol of active enzyme (6 µM × 50 µl).

Designed with a nuclear localization signal (NLS), SniperCas9 efficiently localizes to the nucleus upon delivery. Ideal for microinjection into embryos or low-volume CRISPR workflows, this high-purity protein supports knockout, knock-in, and precise point editing with minimal off-target risk.

Supplied in a 50 µg lyophilized format, SniperCas9 is recommended for RNP assembly with sgRNA and is compatible with microinjection, electroporation, or lipofection methods.

• High fidelity Cas9 variant with low off-target activity
• Reconstitutes to 1 mg/ml
• Supplied as lyophilized 50 µg format
• NLS-tagged for fast nuclear entry
• Compatible with all CRISPR delivery platforms
• Trusted for embryo editing, point mutation correction, and gene therapy research

• Precision gene editing using CRISPR RNP
• Microinjection for in vivo knockout/knock-in
• Gene correction in embryonic and stem cells
• Low off-target editing in therapeutic studies
• Genome editing in human, mouse, and zebrafish models
• High-specificity screening and cell model development

• 50 µg SniperCas9 (High Fidelity Cas9 Protein)
• Reconstitution and usage instructions
• RNP formation guidance
• Access to scientific support

Need help choosing the best fidelity variant or setting up microinjection? Contact our CRISPR support team for custom advice and optimization.