Product Description
TelC-FAM is a C-rich telomere PNA probe designed for FISH-based detection of human telomeres. Labeled with FAM (green fluorophore), it binds the complementary TTAGGG repeat in metaphase chromosomes and interphase nuclei.
Utilizing a non-charged PNA backbone, this probe delivers high signal-to-noise ratios, superior hybridization specificity, and minimal background, making it ideal for aging research, cancer diagnostics, and telomere length analysis. With enhanced photostability and sensitivity, it is compatible with most standard FISH workflows.
Each vial contains 5 nmole, which is usually good enough to stain more than 500 slides.
Support
Need help with fluorescence setup or hybridization optimization? Contact our support team for personalized assistance.
Description
## Product Description
TelC-FAM is a G-rich telomere PNA probe designed for FISH-based detection of human telomeres. Labeled with FAM (green fluorophore), it binds the complementary TTAGGG repeat in metaphase chromosomes and interphase nuclei. Utilizing a non-charged PNA backbone, this probe delivers high signal-to-noise ratios, superior hybridization specificity, and minimal background, making it ideal for aging research, cancer diagnostics, and telomere length analysis. With enhanced photostability and sensitivity, it is compatible with most standard FISH workflows. Each 5 nmole vial enables approximately 100 hybridizations depending on cell/tissue type and protocol.
## Key Features
Binds specifically to TTAGGG human telomere repeat. FAM labeling ensures bright green fluorescence. High specificity and reduced background via PNA chemistry. Ideal for telomere visualization in fixed cells. Compatible with interphase and metaphase FISH. Stable lyophilized format for long-term use
## Applications
Telomere length analysis in senescence and oncology. Cytogenetic studies and metaphase spread imaging. Quantitative FISH (Q-FISH)Chromosome integrity assays. Aging and stem cell research. Clinical and research cytogenetics labs
## What’s Included
5 nmole TelC-FAM PNA probe. Reconstitution and protocol instructions. Access to PNA FISH support team
## Support
Need help with fluorescence setup or hybridization optimization? Contact our support team for personalized assistance.
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